Germline HSD3B1 Genetics and Prostate Cancer Outcomes.
Urology
; 145: 13-21, 2020 11.
Article
de En
| MEDLINE
| ID: mdl-32866512
ABSTRACT
Dihydrotestosterone synthesis in prostate cancer from adrenal DHEA/DHEA-sulfate requires enzymatic conversion in tumor tissues. 3ß-hydroxysteroid dehydrogenase-1 is an absolutely necessary enzyme for such dihydrotestosterone synthesis and is encoded by the gene HSD3B1 which comes in 2 functional inherited forms described in 2013. The adrenal-permissive HSD3B1(1245C) allele allows for rapid dihydrotestosterone synthesis. The adrenal-restrictive HSD3B1(1245A) allele limits androgen synthesis. Studies from multiple cohorts show that adrenal-permissive allele inheritance confers worse outcomes and shorter survival after castration in low-volume prostate cancer and poor outcomes after abiraterone or enzalutamide treatment for castration-resistant prostate cancer. Here, we review the clinical data and implications.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Progesterone reductase
/
Tumeurs de la prostate
/
Steroid isomerases
/
Antagonistes des androgènes
/
Complexes multienzymatiques
Limites:
Humans
/
Male
Langue:
En
Journal:
Urology
Année:
2020
Type de document:
Article