Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells.
Neuron
; 108(2): 349-366.e6, 2020 10 28.
Article
de En
| MEDLINE
| ID: mdl-32877641
ABSTRACT
Neural stem cells (NSCs) in the dentate gyrus (DG) reside in a specialized local niche that supports their neurogenic proliferation to produce adult-born neurons throughout life. How local niche cells interact at the circuit level to ensure continuous neurogenesis from NSCs remains unknown. Here we report the role of endogenous neuropeptide cholecystokinin (CCK), released from dentate CCK interneurons, in regulating neurogenic niche cells and NSCs. Specifically, stimulating CCK release supports neurogenic proliferation of NSCs through a dominant astrocyte-mediated glutamatergic signaling cascade. In contrast, reducing dentate CCK induces reactive astrocytes, which correlates with decreased neurogenic proliferation of NSCs and upregulation of genes involved in immune processes. Our findings provide novel circuit-based information on how CCK acts on local astrocytes to regulate the key behavior of adult NSCs.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Neuropeptides
/
Cholécystokinine
/
Astrocytes
/
Gyrus denté
/
Neurogenèse
/
Cellules souches neurales
/
Interneurones
Limites:
Animals
Langue:
En
Journal:
Neuron
Sujet du journal:
NEUROLOGIA
Année:
2020
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique