Multi-drug resistant, biofilm-producing high-risk clonal lineage of Klebsiella in companion and household animals.
Lett Appl Microbiol
; 71(6): 580-587, 2020 Dec.
Article
de En
| MEDLINE
| ID: mdl-32881009
ABSTRACT
Antimicrobial resistance is a global emergency which needs one health approach to address. The present study was conducted to detect the prevalence of beta-lactamase and biofilm-producing Klebsiella strains in rectal swabs (n = 624) collected from healthy dogs, cats, sheep and goats reared as companion or household animals in India. The dogs and cats were frequently exposed to third- or fourth-generation cephalosporins for therapy. The sheep and goats were occasionally exposed to antibiotics and had environmental exposure. Phenotypical ESBL (n = 93) and ACBL (n = 88)-producing Klebsiella were isolated significantly more (P < 0·05) from companion animals than household animals. Majority of the Klebsiella possessed blaCTX-M-15 . The sequences blaCTX-M-15.2 , blaCTX-M-197 and blaCTX-M-225 are reported first time from the companion animals. All ACBL-producing isolates possessed blaAmpC . The present study detected 65·8% of Klebsiella strains as biofilm producers possessing the studied biofilm associated genes. The isolates showed phenotypical resistance against chloramphenicol, tetracycline, doxycycline, co-trimoxazole, ampicillin, cefotaxime/clavulanic acid. The present study showed that companion and household animals (dogs, cats, sheep, goats) may act as a carrier of ESBL/biofilm-producing, multi-drug resistant, high-risk clonal lineage of Klebsiella.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Biofilms
/
Multirésistance bactérienne aux médicaments
/
Bétail
/
Animaux de compagnie
/
Klebsiella
Type d'étude:
Etiology_studies
/
Risk_factors_studies
Limites:
Animals
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Lett Appl Microbiol
Sujet du journal:
MICROBIOLOGIA
Année:
2020
Type de document:
Article
Pays d'affiliation:
Inde