Inhaled RNA Therapy: From Promise to Reality.
Trends Pharmacol Sci
; 41(10): 715-729, 2020 10.
Article
de En
| MEDLINE
| ID: mdl-32893004
ABSTRACT
RNA-based medicine is receiving growing attention for its diverse roles and potential therapeutic capacity. The largest obstacle in its clinical translation remains identifying a safe and effective delivery system. Studies investigating RNA therapeutics in pulmonary diseases have rapidly expanded and drug administration by inhalation allows the direct delivery of RNA therapeutics to the target site of action while minimizing systemic exposure. In this review, we highlight recent developments in pulmonary RNA delivery systems with the use of nonviral vectors. We also discuss the major knowledge gaps that require thorough investigation and provide insights that will help advance this exciting field towards the bedside.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
ARN
Limites:
Humans
Langue:
En
Journal:
Trends Pharmacol Sci
Année:
2020
Type de document:
Article
Pays d'affiliation:
Australie