Mother's Own Milk Biomarkers Predict Coming to Volume in Pump-Dependent Mothers of Preterm Infants.
J Pediatr
; 228: 44-52.e3, 2021 01.
Article
de En
| MEDLINE
| ID: mdl-32916143
ABSTRACT
OBJECTIVE:
To assess serial secretory activation biomarker concentrations (sodium [Na], potassium [K], NaK, protein, lactose, and citrate) in mother's own milk (MOM) from breast pump-dependent mothers of preterm infants to determine associations with coming to volume (CTV), defined as producing at least 500 mL/day MOM by day 14 postpartum. STUDYDESIGN:
We collected serial MOM samples and pumped MOM volume data for 14 days postpartum in mothers who delivered at <33 weeks of gestation. Regression models and the Mann-Whitney U test were used to evaluate associations.RESULTS:
Among 40 mothers, 39 (mean gestational age, 28.8 weeks; 67% overweight/obese; 59% nonwhite) had paired MOM volume and biomarker data; 33% achieved CTV between postpartum days 6 and 14. In univariate models, MOM Na on postpartum day 5 and NaK on days 3 and 5 were associated with CTV. Mothers achieving CTV were more likely to have postpartum NaK ≤1 on day 3 (75% vs 25%; P = .06) and ≤0.8 on day 5 (69% vs 10%; P < .01). In a multivariable regression model, day 5 NaK (1 unit decrease in NaK OR, 18.7; 95% CI, 1.13-311.41; P = .049) and maternal prepregnancy body mass index (BMI) (1 unit increase in BMI OR, 0.88; 95% CI, 0.78-0.99; P = .04) were associated with CTV between postpartum days 6 and 14.CONCLUSIONS:
Secretory activation and CTV were compromised in breast pump-dependent mothers with preterm delivery. CTV was predicted by MOM Na level and NaK. These biomarkers have potential as objective point-of-care measures to detect potentially modifiable lactation problems in a high-risk population.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Allaitement naturel
/
Nourrisson très faible poids naissance
/
Extraction du lait maternel
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Lait humain
/
Mères
Type d'étude:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adult
/
Female
/
Humans
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Male
/
Newborn
Langue:
En
Journal:
J Pediatr
Année:
2021
Type de document:
Article