PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.

Hou, Junwei; Zhao, Rongce; Xia, Weiya; Chang, Chiung-Wen; You, Yun; Hsu, Jung-Mao; Nie, Lei; Chen, Yeh; Wang, Yu-Chuan; Liu, Chunxiao; Wang, Wei-Jan; Wu, Yun; Ke, Baozhen; Hsu, Jennifer L; Huang, Kebin; Ye, Zu; Yang, Yi; Xia, Xianghou; Li, Yintao; Li, Chia-Wei; Shao, Bin; Tainer, John A; Hung, Mien-Chie

Hou, Junwei; Zhao, Rongce; Xia, Weiya; Chang, Chiung-Wen; You, Yun; Hsu, Jung-Mao; Nie, Lei; Chen, Yeh; Wang, Yu-Chuan; Liu, Chunxiao; Wang, Wei-Jan; Wu, Yun; Ke, Baozhen; Hsu, Jennifer L; Huang, Kebin; Ye, Zu; Yang, Yi; Xia, Xianghou; Li, Yintao; Li, Chia-Wei; Shao, Bin; Tainer, John A; Hung, Mien-Chie.

Affiliation

Hou J; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Zhao R; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xia W; Department of Liver Surgery and Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu, China.
Chang CW; Department of Liver Surgery, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
You Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hsu JM; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nie L; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Chen Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wang YC; Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.
Liu C; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wang WJ; Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.
Wu Y; Institute of New Drug Development, China Medical University, Taichung, Taiwan.
Ke B; Graduate Institute of Biomedical Sciences, Research Center for Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung, Taiwan.
Hsu JL; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Huang K; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Ye Z; Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Yang Y; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xia X; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Li Y; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Li CW; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Shao B; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin, China.
Tainer JA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hung MC; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nat Cell Biol ; 22(10): 1264-1275, 2020 10.

Article de En | MEDLINE | ID: mdl-32929201

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Marqueurs biologiques tumoraux / Régulation de l'expression des gènes tumoraux / Apoptose / Protéines de liaison à l'ADN / Antigène CD274 / Pyroptose / Tumeurs Type d'étude: Prognostic_studies Limites: Animals / Female / Humans Langue: En Journal: Nat Cell Biol Année: 2020 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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