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2-Anilinoquinoline based arylamides as broad spectrum anticancer agents with B-RAFV600E/C-RAF kinase inhibitory effects: Design, synthesis, in vitro cell-based and oncogenic kinase assessments.
El-Damasy, Ashraf K; Haque, Md Mamunul; Park, Jung Woo; Shin, Sang Chul; Lee, Jun-Seok; EunKyeong Kim, Eunice; Keum, Gyochang.
Affiliation
  • El-Damasy AK; Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangro 14-gil 5, Seongbuk-gu, Seoul, 136-791, Republic of Korea; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. Electronic address: ashraf.el
  • Haque MM; Molecular Recognition Research Center, KIST, Seoul, 02792, Republic of Korea.
  • Park JW; Center for Supercomputing Applications, Div. of National Supercomputing R&D, Korea Institute of Science and Technology Information, 245, Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
  • Shin SC; Biomedical Research Institute, KIST, Hwarangro 14-gil 5, Seongbuk-gu, Seoul, 02792, Republic of Korea.
  • Lee JS; Molecular Recognition Research Center, KIST, Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul, 02792, Republic of Korea.
  • EunKyeong Kim E; Biomedical Research Institute, KIST, Hwarangro 14-gil 5, Seongbuk-gu, Seoul, 02792, Republic of Korea.
  • Keum G; Center for Neuro-Medicine, Brain Science Institute, Korea Institute of Science and Technology (KIST), Hwarangro 14-gil 5, Seongbuk-gu, Seoul, 136-791, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST), Seoul, 02792, Rep
Eur J Med Chem ; 208: 112756, 2020 Dec 15.
Article de En | MEDLINE | ID: mdl-32942186
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Quinoléines / Acrylamides / Protéines proto-oncogènes B-raf / Inhibiteurs de protéines kinases / Dérivés de l'aniline / Antinéoplasiques Limites: Animals / Humans Langue: En Journal: Eur J Med Chem Année: 2020 Type de document: Article Pays de publication: France
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Quinoléines / Acrylamides / Protéines proto-oncogènes B-raf / Inhibiteurs de protéines kinases / Dérivés de l'aniline / Antinéoplasiques Limites: Animals / Humans Langue: En Journal: Eur J Med Chem Année: 2020 Type de document: Article Pays de publication: France