A mutant form of ER&#945; associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment.

Li, Yin; Coons, Laurel A; Houtman, René; Carlson, Kathryn E; Martin, Teresa A; Mayne, Christopher G; Melchers, Diana; Jefferson, Tanner B; Ramsey, J Tyler; Katzenellenbogen, John A; Korach, Kenneth S

A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment.

Li, Yin; Coons, Laurel A; Houtman, René; Carlson, Kathryn E; Martin, Teresa A; Mayne, Christopher G; Melchers, Diana; Jefferson, Tanner B; Ramsey, J Tyler; Katzenellenbogen, John A; Korach, Kenneth S.

Affiliation

Li Y; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA. liy4@niehs.nih.gov Korach@niehs.nih.gov.
Coons LA; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA.
Houtman R; Precision Medicine Lab, Kloosterstraat 9, 5349 AB, Oss, Netherlands.
Carlson KE; Department of Chemistry and Cancer Center, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Martin TA; Department of Chemistry and Cancer Center, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Mayne CG; Department of Chemistry and Cancer Center, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Melchers D; Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Jefferson TB; Precision Medicine Lab, Kloosterstraat 9, 5349 AB, Oss, Netherlands.
Ramsey JT; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA.
Katzenellenbogen JA; Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA.
Korach KS; Department of Chemistry and Cancer Center, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Sci Signal ; 13(650)2020 09 22.

Article de En | MEDLINE | ID: mdl-32963012

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Mutation faux-sens / Récepteur alpha des oestrogènes / Oestrogènes / Coactivateur-1 de récepteur nucléaire / Coactivateur-3 de récepteur nucléaire Type d'étude: Prognostic_studies / Risk_factors_studies Limites: Humans Langue: En Journal: Sci Signal Sujet du journal: CIENCIA / FISIOLOGIA Année: 2020 Type de document: Article

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