IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex.

Davila-Calderon, Jesse; Patwardhan, Neeraj N; Chiu, Liang-Yuan; Sugarman, Andrew; Cai, Zhengguo; Penutmutchu, Srinivasa R; Li, Mei-Ling; Brewer, Gary; Hargrove, Amanda E; Tolbert, Blanton S

Davila-Calderon, Jesse; Patwardhan, Neeraj N; Chiu, Liang-Yuan; Sugarman, Andrew; Cai, Zhengguo; Penutmutchu, Srinivasa R; Li, Mei-Ling; Brewer, Gary; Hargrove, Amanda E; Tolbert, Blanton S.

Affiliation

Davila-Calderon J; Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA.
Patwardhan NN; Department of Chemistry, Duke University, Durham, NC, USA.
Chiu LY; Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA.
Sugarman A; Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA.
Cai Z; Department of Chemistry, Duke University, Durham, NC, USA.
Penutmutchu SR; Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA.
Li ML; Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA.
Brewer G; Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, USA. brewerga@rwjms.rutgers.edu.
Hargrove AE; Department of Chemistry, Duke University, Durham, NC, USA. amanda.hargrove@duke.edu.
Tolbert BS; Department of Chemistry, Case Western Reserve University, Cleveland, OH, USA. blanton.tolbert@case.edu.

Nat Commun ; 11(1): 4775, 2020 09 22.

Article de En | MEDLINE | ID: mdl-32963221

Sujet(s)

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Réplication virale / Entérovirus humain A / Infections à entérovirus / Interactions hôte-pathogène / Sites internes d'entrée des ribosomes Limites: Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2020 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

Texte intégral

Ajouter à My VHL

Imprimer

XML

PubMed Links

Recherche sur Google