Organocatalytic Enantioselective Conjugate Alkynylation of ß-Aminoenones: Access to Chiral ß-Alkynyl-ß-Amino Carbonyl Derivatives.
Org Lett
; 22(19): 7427-7432, 2020 10 02.
Article
de En
| MEDLINE
| ID: mdl-32966092
ABSTRACT
Readily available potassium alkynyltrifluoroborates were used for organocatalytic asymmetric conjugate alkynylation of ß-enaminones. The interception of a modified binaphthol catalyst and in situ generated organodifluoroboranes proved important to access functionalized ß-alkynyl-ß-amino carbonyls and derivatives with improved chemo-reactivity and enantio-induction. Mechanistic studies revealed the impact of molecular sieves on efficiency and stereocontrol. The products undergo additional functionalization to yield a diverse set of valuable ß-alkynyl-ß-amino carbonyl scaffolds.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
Org Lett
Sujet du journal:
BIOQUIMICA
Année:
2020
Type de document:
Article