Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres.
Future Med Chem
; 12(20): 1855-1864, 2020 10.
Article
de En
| MEDLINE
| ID: mdl-33012189
ABSTRACT
Aim:
Thiazolidinones were prepared as building blocks for the replacement of carboxylic acids. Materials &methods:
Chemical syntheses of thiazolidinones were developed. In addition, the drug-likeness of the target compounds was evaluated in silico.Results:
The prepared compounds included the novel structure 4; 5-(3-Iodophenylmethylene)-2,4-thiazolidinedione.Conclusion:
Exploration of the methods required to synthesize thiazolidinone building blocks was completed. This work allows future generation of bioisosteric analogs of drugs.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Acides carboxyliques
/
Thiazolidinediones
Langue:
En
Journal:
Future Med Chem
Année:
2020
Type de document:
Article
Pays d'affiliation:
Royaume-Uni