Circulating miRNA-23b and miRNA-143 Are Potential Biomarkers for In-Stent Restenosis.
Biomed Res Int
; 2020: 2509039, 2020.
Article
de En
| MEDLINE
| ID: mdl-33015157
ABSTRACT
In-stent restenosis (ISR) is one of the main complications in patients undergoing percutaneous coronary angioplasty, and microRNAs participate in the contractile-to-synthetic phenotypic switch of vascular smooth muscle cells, a hallmark of restenosis development. MicroRNAs (miRNAs) can be released into circulation from injured tissues, enticing a potential role as noninvasive biomarkers. We aimed to evaluate circulating levels of miRNA-23b, miRNA-143, and miRNA-145 as diagnostic markers of ISR. 142 patients with coronary artery disease undergoing successful angioplasty and a follow-up angiography were included. Subjects were classified according to the degree of obstruction at the angioplasty site into cases (≥50%) or controls (<50%). Total RNA was isolated from plasma to quantify circulating miRNAs levels, and the ROC curves were constructed. Among circulating miRNAs assessed, miRNA-23b and miRNA-143 were significantly lower in cases (miRNA-23b 18.4x10-5 and miRNA-143 13.7x10-5) than controls (miRNA-23b 5.2x10-5, p < 0.0001; miRNA-143 4.0x10-5, p < 0.0001). Plasma levels of miRNA-145 showed no significant differences. The analysis of the ROC curves showed an area under the curve for miRNA-23b of 0.71 (95% CI 0.62-0.80, p < 0.0001) and 0.69 for miRNA-143 (95% CI 0.60-0.78; p < 0.0001). Our data suggest that plasma levels of miRNA-23b and miRNA-143 could be useful as noninvasive biomarkers of ISR.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Marqueurs biologiques
/
Resténose coronaire
/
MicroARN
/
MicroARN circulant
Type d'étude:
Prognostic_studies
/
Risk_factors_studies
Limites:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Biomed Res Int
Année:
2020
Type de document:
Article
Pays d'affiliation:
Chili