Cost-utility analysis of newborn hepatitis B immunization in Beijing.
Hum Vaccin Immunother
; 17(4): 1196-1204, 2021 04 03.
Article
de En
| MEDLINE
| ID: mdl-33016814
ABSTRACT
OBJECTIVES:
To evaluate cost-utility of universal Hepatitis B vaccination program in the Beijing city (Beijing).METHODS:
A decision-Markov model was constructed to determine the cost-utility of the universal immunization program for infants (universal vaccination program) by comparing with a hypothetic nonvaccination strategy in Beijing. Parameters in models were extracted from Beijing Center for Disease Control and Prevention (CDC) annual work report, Beijing health statistical yearbook, National Health Survey report, Beijing 1% population sample survey report, Beijing Health and Medical Price Monitoring Data Platform, and public literatures. The incremental costutility ratio (ICUR) was used to compare alternative scenarios. One-way sensitivity analysis and probabilistic sensitivity analysis were used to assess parameter uncertainties.RESULTS:
The universal vaccination program had increased the utility and reduced cost among infants born in 2016 in Beijing. The ICUR was CNY -24,576.61 (US$ -3779.16) per QALY for universal vaccination program comparing with non-vaccination scenario from healthcare perspective. It was estimated that the universal vaccination would save direct medical treatment cost of CNY 2,262,869,173.50 (US$ 347,962,414.43) and prevent loss of 18322.25 QALYs within lifetime of target cohort. Discount rate accounted for the most remarkable influence on ICUR in one-way sensitivity analysis. The result of probabilistic sensitivity analysis illustrated that all of the ICURs were located in the fourth quadrant of the cost-utility incremental plot undergone 5000 times of Monte Carlo simulation.CONCLUSIONS:
Current universal hepatitis B vaccination program in Beijing was highly cost utility. The investment was reasonable for current universal vaccination program in Beijing.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Programmes de vaccination
/
Hépatite B
Type d'étude:
Health_economic_evaluation
/
Prognostic_studies
Aspects:
Patient_preference
Limites:
Child, preschool
/
Humans
/
Infant
/
Newborn
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Hum Vaccin Immunother
Année:
2021
Type de document:
Article
Pays d'affiliation:
Chine