lncRNAKB, a knowledgebase of tissue-specific functional annotation and trait association of long noncoding RNA.
Sci Data
; 7(1): 326, 2020 10 05.
Article
de En
| MEDLINE
| ID: mdl-33020484
ABSTRACT
Long non-coding RNA Knowledgebase (lncRNAKB) is an integrated resource for exploring lncRNA biology in the context of tissue-specificity and disease association. A systematic integration of annotations from six independent databases resulted in 77,199 human lncRNA (224,286 transcripts). The user-friendly knowledgebase covers a comprehensive breadth and depth of lncRNA annotation. lncRNAKB is a compendium of expression patterns, derived from analysis of RNA-seq data in thousands of samples across 31 solid human normal tissues (GTEx). Thousands of co-expression modules identified via network analysis and pathway enrichment to delineate lncRNA function are also accessible. Millions of expression quantitative trait loci (cis-eQTL) computed using whole genome sequence genotype data (GTEx) can be downloaded at lncRNAKB that also includes tissue-specificity, phylogenetic conservation and coding potential scores. Tissue-specific lncRNA-trait associations encompassing 323 GWAS (UK Biobank) are also provided. LncRNAKB is accessible at http//www.lncrnakb.org/ , and the data are freely available through Open Science Framework ( https//doi.org/10.17605/OSF.IO/RU4D2 ).
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Spécificité d'organe
/
Bases de connaissances
/
ARN long non codant
Type d'étude:
Prognostic_studies
/
Risk_factors_studies
Limites:
Humans
Langue:
En
Journal:
Sci Data
Année:
2020
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique