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Sensory nerves in the spotlight of the stem cell niche.
Picoli, Caroline C; Costa, Alinne C; Rocha, Beatriz G S; Silva, Walison N; Santos, Gabryella S P; Prazeres, Pedro H D M; Costa, Pedro A C; Oropeza, Anderson; da Silva, Rodrigo A; Azevedo, Vasco A C; Resende, Rodrigo R; Cunha, Thiago M; Mintz, Akiva; Birbrair, Alexander.
Affiliation
  • Picoli CC; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Costa AC; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Rocha BGS; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Silva WN; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Santos GSP; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Prazeres PHDM; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Costa PAC; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Oropeza A; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • da Silva RA; Department of Dentistry, University of Taubaté, Taubaté, São Paulo, Brazil.
  • Azevedo VAC; Cellular and Molecular Genetics Laboratory, Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Resende RR; Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Cunha TM; Department of Pharmacology, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Mintz A; Department of Radiology, Columbia University Medical Center, New York, New York, USA.
  • Birbrair A; Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Stem Cells Transl Med ; 10(3): 346-356, 2021 03.
Article de En | MEDLINE | ID: mdl-33112056
ABSTRACT
Niches are specialized tissue microenvironments that control stem cells functioning. The bone marrow mesenchymal stem cell niche defines a location within the marrow in which mesenchymal stem cells are retained and produce new cells throughout life. Deciphering the signaling mechanisms by which the niche regulates stem cell fate will facilitate the use of these cells for therapy. Recent studies, by using state-of-the-art methodologies, including sophisticated in vivo inducible genetic techniques, such as lineage-tracing Cre/loxP mediated systems, in combination with pharmacological inhibition, provide evidence that sensory neuron is an important component of the bone marrow mesenchymal stem cell niche. Strikingly, knockout of a specific receptor in sensory neurons blocked stem cell function in the bone marrow. The knowledge arising from these discoveries will be crucial for stem cell manipulation in the future. Here, we review recent progress in our understanding of sensory nerves biology in the stem cell niche.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cellules réceptrices sensorielles / Niche de cellules souches / Cellules souches mésenchymateuses Langue: En Journal: Stem Cells Transl Med Année: 2021 Type de document: Article Pays d'affiliation: Brésil
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Cellules réceptrices sensorielles / Niche de cellules souches / Cellules souches mésenchymateuses Langue: En Journal: Stem Cells Transl Med Année: 2021 Type de document: Article Pays d'affiliation: Brésil