Epidemiological changes in cutaneous lymphomas: an analysis of 8593 patients from the French Cutaneous Lymphoma Registry.
Br J Dermatol
; 184(6): 1059-1067, 2021 06.
Article
de En
| MEDLINE
| ID: mdl-33131055
ABSTRACT
BACKGROUND:
Primary cutaneous lymphomas (PCLs) are a heterogeneous group of T-cell (CTCL) and B-cell (CBCL) malignancies. Little is known about their epidemiology at initial presentation in Europe and about potential changes over time.OBJECTIVES:
The aim of this retrospective study was to analyse the frequency of PCLs in the French Cutaneous Lymphoma Registry (GFELC) and to describe the demography of patients.METHODS:
Patients with a centrally validated diagnosis of primary PCL, diagnosed between 2005 and 2019, were included.RESULTS:
The calculated incidence was unprecedently high at 1·06 per 100 000 person-years. The number of included patients increased yearly. Most PCL subtypes were more frequent in male patients, diagnosed at a median age of 60 years. The relative frequency of rare CTCL remained stable, the proportion of classical mycosis fungoides (MF) decreased, and the frequency of its variants (e.g. folliculotropic MF) increased. Similar patterns were observed for CBCL; for example, the proportion of marginal-zone CBCL increased over time.CONCLUSIONS:
Changes in PCL frequencies may be explained by the emergence of new diagnostic criteria and better description of the entities in the most recent PCL classification. Moreover, we propose that an algorithm should be developed to confirm the diagnosis of PCL by central validation of the cases.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs cutanées
/
Lymphome B
/
Lymphome T cutané
/
Mycosis fongoïde
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites:
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
Br J Dermatol
Année:
2021
Type de document:
Article
Pays d'affiliation:
France