Whole Exome Sequencing of SMO, BRAF, PTCH1 and GNAS in Odontogenic Diseases.
In Vivo
; 34(6): 3233-3240, 2020.
Article
de En
| MEDLINE
| ID: mdl-33144428
ABSTRACT
BACKGROUND/AIM:
Odontogenic diseases are diagnosed based on clinical course, imaging, and histopathology. However, a definitive diagnosis is not always possible. PATIENTS ANDMETHODS:
We analyzed whole exons of SMO, BRAF, PTCH1 and GNAS using next-generation sequencing (NGS) in 18 patients.RESULTS:
Of the 6 patients with ameloblastoma, 2 patients had the same missense mutation in BRAF, and 1 patient with peripheral ameloblastoma had a missense mutation in PTCH1. Of the 7 patients with odontogenic keratocyst, 4 patients had a missense mutation in PTCH1, 2 patients had missense mutations in BRAF, and 1 patient had a missense mutation in SMO. The patient with odontoma had missense mutations in SMO, BRAF and PTCH1. One patient with cement-osseous dysplasia had missense mutations in SMO and PTCH1. The patient with adenomatoid odontogenic tumor had missense mutations in SMO.CONCLUSION:
Whole exome sequencing of the above genes by NGS would be useful for the differential diagnosis of odontogenic diseases.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Améloblastome
/
Kystes odontogènes
/
Tumeurs odontogènes
Limites:
Humans
Langue:
En
Journal:
In Vivo
Sujet du journal:
NEOPLASIAS
Année:
2020
Type de document:
Article
Pays d'affiliation:
Japon