Prognostic impact of lung adenocarcinoma second predominant pattern from a large European database.
J Surg Oncol
; 123(2): 560-569, 2021 Feb.
Article
de En
| MEDLINE
| ID: mdl-33169397
ABSTRACT
BACKGROUND AND OBJECTIVES:
Adenocarcinoma patterns could be grouped based on clinical behaviors low- (lepidic), intermediate- (papillary or acinar), and high-grade (micropapillary and solid). We analyzed the impact of the second predominant pattern (SPP) on disease-free survival (DFS).METHODS:
We retrospectively collected data of surgically resected stage I and II adenocarcinoma. SELECTION CRITERIA anatomical resection with lymphadenectomy and pathological N0. Pure adenocarcinomas and mucinous subtypes were excluded. Recurrence rate and factors affecting DFS were analyzed according to the SPP focusing on intermediate-grade predominant pattern adenocarcinomas.RESULTS:
Among 270 patients, 55% were male. The mean age was 68.3 years. SPP pattern appeared as follows lepidic 43.0%, papillary 23.0%, solid 14.4%, acinar 11.9%, and micropapillary 7.8%. The recurrence rate was 21.5% and 5-year DFS was 71.1%. No difference in DFS was found according to SPP (p = .522). In patients with high-grade SPP, the percentage of SPP, age, and tumor size significantly influenced DFS (p = .016). In patients with lepidic SPP, size, male gender, and lymph-node sampling (p = .005; p = .014; p = .038, respectively) significantly influenced DFS.CONCLUSIONS:
The impact of SPP on DFS is not homogeneous in a subset of patients with the intermediate-grade predominant patterns. The influence of high-grade SPP on DFS is related to its proportion in the tumor.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Adénocarcinome papillaire
/
Bases de données factuelles
/
Carcinome à cellules acineuses
/
Adénocarcinome pulmonaire
/
Tumeurs du poumon
/
Récidive tumorale locale
Type d'étude:
Observational_studies
/
Prognostic_studies
Limites:
Aged
/
Female
/
Humans
/
Male
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
J Surg Oncol
Année:
2021
Type de document:
Article
Pays d'affiliation:
Italie