[Research progress of Pictet-Spenglerases].
Sheng Wu Gong Cheng Xue Bao
; 36(10): 2001-2016, 2020 Oct 25.
Article
de Zh
| MEDLINE
| ID: mdl-33169566
Pictet-Spenglerases (P-Sases) catalyze the Pictet-Spengler (P-S) reactions and exhibit high stereoselectivity and regioselectivity under mild conditions. The typical P-S reaction refers to the condensation and recyclization of ß-arylethylamine with aldehyde or ketone under acidic conditions to form tetrahydroisoquinoline and ß-carboline alkaloid derivatives. The related enzymatic products of P-Sases are the backbones of various bioactive compounds, including clinical drugs: morphine, noscapine, quinine, berberine, ajmaline, morphine. Furthermore, the activity of P-Sases in stereoselective and regioselective catalysis is also valuable for chemoenzymatic synthesis. Therefore, this review summarizes the research progress in the discovery, functional identification, biological characteristics and catalytic applications of P-Sases, which provide the useful theoretical reference in future P-Sases research and development.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Recherche
/
Tétrahydroisoquinoléines
/
Alcaloïdes
/
Enzymes
Type d'étude:
Prognostic_studies
Langue:
Zh
Journal:
Sheng Wu Gong Cheng Xue Bao
Sujet du journal:
BIOTECNOLOGIA
Année:
2020
Type de document:
Article
Pays d'affiliation:
Chine
Pays de publication:
Chine