Hospitalization rates and 30-day all-cause mortality among head and neck cancer patients and survivors with COVID-19.
Oral Oncol
; 112: 105087, 2021 01.
Article
de En
| MEDLINE
| ID: mdl-33190021
ABSTRACT
BACKGROUND:
The impact of COVID-19 on patients with cancer is emerging, but data are urgently needed for head and neck cancer (HNC) patients or survivors who are inherently high-risk for severe illness and mortality with SARS-CoV-2 infection.METHODS:
This multi-institution, academic cohort study collected comprehensive data on clinical risk factors, COVID-19 symptoms and viral testing patterns, information about hospitalization rates, and predictors of survival among HNC patients with active disease or in remission. The primary endpoint was 30-day all-cause mortality from the date of confirmed COVID-19. We performed multivariate analysis to understand the prognostic value of clinical and laboratory parameters on outcomes.RESULTS:
Thirty-two patients with COVID-19 and HNC were included. Median age was 70 (range 38-91) with 38% aged 75+, and 34% resided in long-term care facilities (LTCF). Thirteen (41%) had active cancer, with 6 (19%) on cancer therapy within 4 weeks of COVID-19 diagnosis. New or worsening cough and fatigue were the most commonly reported presenting symptoms. More than 30% required >1 SARS-CoV-2 test before confirming a positive result. Twenty (63%) required hospitalization. At data cutoff, 7 (22%) had died (1 on active cancer treatment), with a 30-day all-cause mortality of 18.9% (95%CI 11.4-33.6) among all patients, and 71.5% (95%CI 38.2-92.3) among those requiring intensive care unit (ICU) admission. ICU admission and residing in a LTCF predicted worse outcomes (p < 0.01), while age, gender, and recent treatment did not.CONCLUSIONS:
We observed high 30-day all-cause mortality among HNC patients with COVID-19, but most were not on active cancer therapy.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Survivants du cancer
/
SARS-CoV-2
/
COVID-19
/
Tumeurs de la tête et du cou
/
Hospitalisation
Type d'étude:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Oral Oncol
Sujet du journal:
NEOPLASIAS
Année:
2021
Type de document:
Article