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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia.
Bhatt, Shruti; Pioso, Marissa S; Olesinski, Elyse Anne; Yilma, Binyam; Ryan, Jeremy A; Mashaka, Thelma; Leutz, Buon; Adamia, Sophia; Zhu, Haoling; Kuang, Yanan; Mogili, Abhishek; Louissaint, Abner; Bohl, Stephan R; Kim, Annette S; Mehta, Anita K; Sanghavi, Sneha; Wang, Youzhen; Morris, Erick; Halilovic, Ensar; Paweletz, Cloud P; Weinstock, David M; Garcia, Jacqueline S; Letai, Anthony.
Affiliation
  • Bhatt S; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA; Department of Pharmacy, National University of Singapore, Singapore.
  • Pioso MS; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA.
  • Olesinski EA; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA.
  • Yilma B; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA.
  • Ryan JA; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA.
  • Mashaka T; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA.
  • Leutz B; Department of Bioinformatics and Data Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Adamia S; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA.
  • Zhu H; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA.
  • Kuang Y; Department of Bioinformatics and Data Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Mogili A; Department of Bioinformatics and Data Science, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Louissaint A; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA.
  • Bohl SR; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA.
  • Kim AS; Harvard Medical School, Boston, MA, USA; Brigham and Women's Hospital, Boston, MA, USA.
  • Mehta AK; Breast Tumor Immunology Laboratory, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Sanghavi S; Novartis Institutes for BioMedical Research, Inc., Cambridge, MA, USA.
  • Wang Y; Novartis Institutes for BioMedical Research, Inc., Cambridge, MA, USA.
  • Morris E; Novartis Institutes for BioMedical Research, Inc., Cambridge, MA, USA.
  • Halilovic E; Novartis Institutes for BioMedical Research, Inc., Cambridge, MA, USA.
  • Paweletz CP; Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Weinstock DM; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA.
  • Garcia JS; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA.
  • Letai A; Department of Medical Oncology, Dana-Farber Cancer Institute, 440 Brookline Avenue, M430, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: anthony_letai@dfci.harvard.edu.
Cancer Cell ; 38(6): 872-890.e6, 2020 12 14.
Article de En | MEDLINE | ID: mdl-33217342
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrimidines / Sulfonamides / Thiophènes / Leucémie aigüe myéloïde / Résistance aux médicaments antinéoplasiques / Composés hétérocycliques bicycliques / Mitochondries Limites: Animals / Humans Langue: En Journal: Cancer Cell Sujet du journal: NEOPLASIAS Année: 2020 Type de document: Article Pays d'affiliation: Singapour Pays de publication: États-Unis d'Amérique
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyrimidines / Sulfonamides / Thiophènes / Leucémie aigüe myéloïde / Résistance aux médicaments antinéoplasiques / Composés hétérocycliques bicycliques / Mitochondries Limites: Animals / Humans Langue: En Journal: Cancer Cell Sujet du journal: NEOPLASIAS Année: 2020 Type de document: Article Pays d'affiliation: Singapour Pays de publication: États-Unis d'Amérique