Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma.

Federico, Cinzia; Alhallak, Kinan; Sun, Jennifer; Duncan, Kathleen; Azab, Feda; Sudlow, Gail P; de la Puente, Pilar; Muz, Barbara; Kapoor, Vaishali; Zhang, Luna; Yuan, Fangzheng; Markovic, Matea; Kotsybar, Joseph; Wasden, Katherine; Guenthner, Nicole; Gurley, Shannon; King, Justin; Kohnen, Daniel; Salama, Noha N; Thotala, Dinesh; Hallahan, Dennis E; Vij, Ravi; DiPersio, John F; Achilefu, Samuel; Azab, Abdel Kareem

Federico, Cinzia; Alhallak, Kinan; Sun, Jennifer; Duncan, Kathleen; Azab, Feda; Sudlow, Gail P; de la Puente, Pilar; Muz, Barbara; Kapoor, Vaishali; Zhang, Luna; Yuan, Fangzheng; Markovic, Matea; Kotsybar, Joseph; Wasden, Katherine; Guenthner, Nicole; Gurley, Shannon; King, Justin; Kohnen, Daniel; Salama, Noha N; Thotala, Dinesh; Hallahan, Dennis E; Vij, Ravi; DiPersio, John F; Achilefu, Samuel; Azab, Abdel Kareem.

Affiliation

Federico C; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Alhallak K; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Sun J; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Duncan K; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Azab F; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Sudlow GP; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
de la Puente P; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Muz B; Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Kapoor V; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Zhang L; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Yuan F; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Markovic M; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Kotsybar J; Department of Biomedical Engineering, Washington University, St. Louis, MO, USA.
Wasden K; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Guenthner N; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA.
Gurley S; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
King J; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA.
Kohnen D; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Salama NN; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA.
Thotala D; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Hallahan DE; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
Vij R; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, USA.
DiPersio JF; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Achilefu S; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Azab AK; Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, St. Louis, MO, USA.

Nat Commun ; 11(1): 6037, 2020 11 27.

Article de En | MEDLINE | ID: mdl-33247158

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Inhibiteurs de protéines kinases / Nanoparticules / Rho-Associated Kinases / Microenvironnement tumoral / Bortézomib / Myélome multiple Limites: Animals / Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2020 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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