Utility of quantitative contrast-enhanced ultrasound for the prediction of lymph node metastasis in patients with papillary thyroid carcinoma.
Clin Hemorheol Microcirc
; 80(1): 37-48, 2022.
Article
de En
| MEDLINE
| ID: mdl-33252064
ABSTRACT
OBJECTIVES:
The aim of this study was to find the optimal parameters and cutoffs to differentiate metastatic lymph nodes (LNs) from benign LNs in the patients with papillary thyroid carcinoma (PTC) on the quantitative contrast-enhanced ultrasound (CEUS) features.METHODS:
A total of 134âLNs in 105 patients with PTCs were retrospectively enrolled. All LNs were evaluated by conventional ultrasound (US) and CEUS before biopsy or surgery. The diagnostic efficacy of CEUS parameters was analyzed.RESULTS:
Univariate analysis indicated that metastatic LNs more often manifested centripetal or asynchronous perfusion, hyper-enhancement, heterogeneous enhancement, ring-enhancing margins, higher PI, larger AUC, longer TTP and DT/2 than benign LNs at pre-operative CEUS (pâ<â0.001, for all). Multivariate analysis showed that centripetal or asynchronous perfusion (ORâ=â3.163; 95% CI, 1.721-5.812), hyper-enhancement(ORâ=â0.371; 95% CI, 0.150-0.917), DT/2 (ORâ=â7.408; 95% confidence interval CI, 1.496-36.673), and AUC (ORâ=â8.340; 95% CI, 2.677-25.984) were predictive for the presence of metastatic LNs. The sensitivity and accuracy of the quantitative CEUS were higher than qualitative CEUS (75% vs 55 % and 83.6% vs 76.1 %, respectively).CONCLUSIONS:
Quantitative CEUS parameters can provide more information to distinguish metastatic from benign LNs in PTC patients; In particular, DT/2 and AUC have a higher sensitivity and accuracy in predicting the presence of metastatic LNs and reduce unnecessary sampling of benign LNs.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs de la thyroïde
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Qualitative_research
Limites:
Humans
Langue:
En
Journal:
Clin Hemorheol Microcirc
Sujet du journal:
ANGIOLOGIA
/
HEMATOLOGIA
Année:
2022
Type de document:
Article
Pays d'affiliation:
Chine