Adaptive immune responses in channel catfish exposed to Edwardsiella ictaluri live attenuated vaccine and wild type strains through the specific gene expression profiles.
Dev Comp Immunol
; 116: 103950, 2021 03.
Article
de En
| MEDLINE
| ID: mdl-33253752
ABSTRACT
We extend the previous findings on the differential activity of immune-related genes in the lymphoid organs of channel catfish in the 7 days post-challenge (dpc) with E. ictaluri live attenuated vaccines (LAVs) and wild type (WT) strains by assessing the expression of these genes in the 21 dpc. The expression of T and B cell-specific genes were significantly elevated in the spleen at 14 dpc and in the AK at 21 dpc in catfish treated with E. ictaluri WT and LAV strains compared to a non-treated control group. The gene expression of IFN-γ correlated with adaptive immunity genes in the lymphoid tissues of catfish. These data indicate that two novel LAVs were able to trigger the activation of T helper1 polarization cytokine IFN-γ gene and specific lymphocyte genes in the spleen followed by their activation in the AK of catfish without causing inflammation, thus providing protective immunity in E. ictaluri infection.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Ictaluridae
/
Vaccins antibactériens
/
Edwardsiella ictaluri
/
Infections à Enterobacteriaceae
/
Immunité acquise
/
Maladies des poissons
Limites:
Animals
Langue:
En
Journal:
Dev Comp Immunol
Année:
2021
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique