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Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques.
Hoang, Timothy N; Pino, Maria; Boddapati, Arun K; Viox, Elise G; Starke, Carly E; Upadhyay, Amit A; Gumber, Sanjeev; Nekorchuk, Michael; Busman-Sahay, Kathleen; Strongin, Zachary; Harper, Justin L; Tharp, Gregory K; Pellegrini, Kathryn L; Kirejczyk, Shannon; Zandi, Keivan; Tao, Sijia; Horton, Tristan R; Beagle, Elizabeth N; Mahar, Ernestine A; Lee, Michelle Y H; Cohen, Joyce; Jean, Sherrie M; Wood, Jennifer S; Connor-Stroud, Fawn; Stammen, Rachelle L; Delmas, Olivia M; Wang, Shelly; Cooney, Kimberly A; Sayegh, Michael N; Wang, Lanfang; Filev, Peter D; Weiskopf, Daniela; Silvestri, Guido; Waggoner, Jesse; Piantadosi, Anne; Kasturi, Sudhir P; Al-Shakhshir, Hilmi; Ribeiro, Susan P; Sekaly, Rafick P; Levit, Rebecca D; Estes, Jacob D; Vanderford, Thomas H; Schinazi, Raymond F; Bosinger, Steven E; Paiardini, Mirko.
Affiliation
  • Hoang TN; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Pino M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Boddapati AK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Viox EG; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Starke CE; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Upadhyay AA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Gumber S; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Nekorchuk M; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Busman-Sahay K; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Strongin Z; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Harper JL; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Tharp GK; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Pellegrini KL; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Kirejczyk S; Division of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Zandi K; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Tao S; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Horton TR; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Beagle EN; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Mahar EA; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Lee MYH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Cohen J; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Jean SM; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Wood JS; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Connor-Stroud F; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Stammen RL; Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Delmas OM; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Wang S; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Cooney KA; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Sayegh MN; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Wang L; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Filev PD; Department of Radiology and Imaging Sciences, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Weiskopf D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
  • Silvestri G; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Waggoner J; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Piantadosi A; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Kasturi SP; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Al-Shakhshir H; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Ribeiro SP; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Sekaly RP; Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
  • Levit RD; Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA.
  • Estes JD; Vaccine and Gene Therapy Institute, Oregon Health & Science University, Beaverton, OR 97006, USA; Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, USA.
  • Vanderford TH; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
  • Schinazi RF; Center for AIDS Research, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: rschina@emory.edu.
  • Bosinger SE; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Yerkes Genomics Core Laboratory, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of M
  • Paiardini M; Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: mirko.paiardini@emory.edu.
Cell ; 184(2): 460-475.e21, 2021 01 21.
Article de En | MEDLINE | ID: mdl-33278358

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Purines / Pyrazoles / Sulfonamides / Azétidines / Infiltration par les neutrophiles / COVID-19 / Traitements médicamenteux de la COVID-19 / Macaca mulatta / Anti-inflammatoires Limites: Animals Langue: En Journal: Cell Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Purines / Pyrazoles / Sulfonamides / Azétidines / Infiltration par les neutrophiles / COVID-19 / Traitements médicamenteux de la COVID-19 / Macaca mulatta / Anti-inflammatoires Limites: Animals Langue: En Journal: Cell Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique