Natural immunity to influenza A and B among Saudi blood donors in Al Madinah Al Munawarah, Saudi Arabia.
Saudi Med J
; 41(12): 1301-1307, 2020 Dec.
Article
de En
| MEDLINE
| ID: mdl-33294887
ABSTRACT
OBJECTIVES:
To investigate the seroprevalence of influenza viruses (A and B) among blood donors in Kingdom of Saudi Arabia.Methods:
The present investigation was conducted between April 2019 and July 2019. Participants were healthy adults recruited from the central blood bank Al Madinah Al Munawarah, Kingdom of Saudi Arabia. Immunoglobulin G (IgG) levels against influenza A and B were measured in serum samples using ELISA.RESULTS:
The results showed that 29.2% of the sample had significant concentrations of influenza A IgG antibody, whereas 38.6% had significant concentrations of influenza B IgG antibody. A strong correlation was found between the levels of influenza A and influenza B antibodies (r=0.708, p less than 0.001). The number of individuals identified as negative for influenza A IgG antibody increased with age (p less than 0.01). In addition, no correlations were identified between influenza A IgG and influenza B IgG and body mass index (BMI), (p greater than 0.05). Finally, linear regression analysis showed that the level of influenza A antibody can be predicted by age (p less than 0.05) and body mass index (BMI) (p less than 0.05).CONCLUSION:
Approximately one-third of Saudi Arabian adults presented significant levels of influenza A and B antibodies in our study. Demographic factors, including age and BMI, might contribute to influenza A antibody levels.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Virus de la grippe A
/
Virus influenza B
/
Donneurs de sang
/
Immunoglobuline G
/
Grippe humaine
/
Immunité innée
/
Anticorps antiviraux
Type d'étude:
Prognostic_studies
Limites:
Adult
/
Female
/
Humans
/
Male
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Saudi Med J
Année:
2020
Type de document:
Article