Dengue and Plasmodium falciparum Coinfection With Secondary Hemophagocytic Lymphohistiocytosis in a 3-Year-old Boy: A Clinical Conundrum.
J Pediatr Hematol Oncol
; 44(1): e253-e254, 2022 01 01.
Article
de En
| MEDLINE
| ID: mdl-33306604
Hemophagocytic lymphohistiocytosis (HLH) is a multisystem disease wherein there is an exaggerated immune system activation following a trigger such as infection, malignancy, or autoimmune diseases. Here we report a case of a 3-year-old boy who presented to us with fever, was diagnosed with dengue fever, and treatment started for the same. Clinical response was poor to treatment and high-grade fever persisted. Subsequent evaluation showed Plasmodium falciparum malaria and treatment was initiated with antimalarial drugs. Further clinical deterioration with poor trend of laboratory values over the next few days prompted evaluation for HLH; workup was positive satisfying the HLH-2004 criteria and IV dexamethasone was started. The child gradually improved and was discharged with normal counts on follow-up over the next 3 months. This article emphasizes on the importance of high degree of suspicion, early workup, and initiation of treatment for HLH for a better outcome.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Plasmodium falciparum
/
Paludisme à Plasmodium falciparum
/
Dengue
/
Virus de la dengue
/
Lymphohistiocytose hémophagocytaire
Type d'étude:
Diagnostic_studies
Limites:
Child, preschool
/
Humans
/
Male
Langue:
En
Journal:
J Pediatr Hematol Oncol
Sujet du journal:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Année:
2022
Type de document:
Article
Pays d'affiliation:
Inde
Pays de publication:
États-Unis d'Amérique