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Differential Binding of Sarilumab and Tocilizumab to IL-6Rα and Effects of Receptor Occupancy on Clinical Parameters.
Xu, Christine; Rafique, Ashique; Potocky, Terra; Paccaly, Anne; Nolain, Patrick; Lu, Qiang; Iglesias-Rodriguez, Melitza; St John, Gregory; Nivens, Michael C; Kanamaluru, Vanaja; Fairhurst, Jeanette; Ishii, Tomonori; Maldonado, Rafael; Choy, Ernest; Emery, Paul.
Affiliation
  • Xu C; Translational Medicine and Early Development, Sanofi, Bridgewater, New Jersey, USA.
  • Rafique A; Therapeutic Proteins, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
  • Potocky T; Bioassay Development, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
  • Paccaly A; Immunology, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
  • Nolain P; Research and Development, Sanofi-Aventis, Montpellier, France.
  • Lu Q; Modeling and Simulation, Pharmacokinetics, Dynamics, and Metabolism, Sanofi, Bridgewater, New Jersey, USA.
  • Iglesias-Rodriguez M; Medical Affairs, Sanofi Genzyme, Cambridge, Massachusetts, USA.
  • St John G; Immunology and Inflammation, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
  • Nivens MC; Strategic Program Direction, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
  • Kanamaluru V; Pharmacokinetics, Dynamics, and Metabolism, Sanofi, Bridgewater, New Jersey, USA.
  • Fairhurst J; Therapeutic Proteins, Regeneron Pharmaceuticals, Inc., Tarrytown, New York, USA.
  • Ishii T; Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
  • Maldonado R; Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain.
  • Choy E; Department of Medicine, Cardiff University School of Medicine, Cardiff, UK.
  • Emery P; Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
J Clin Pharmacol ; 61(5): 714-724, 2021 05.
Article de En | MEDLINE | ID: mdl-33314148
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Protéine C-réactive / Antirhumatismaux / Récepteurs à l'interleukine-6 / Anticorps monoclonaux humanisés Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: J Clin Pharmacol Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Protéine C-réactive / Antirhumatismaux / Récepteurs à l'interleukine-6 / Anticorps monoclonaux humanisés Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: J Clin Pharmacol Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: Royaume-Uni