Two independent mouse lines carrying the Nav1.7 I228M gain-of-function variant display dorsal root ganglion neuron hyperexcitability but a minimal pain phenotype.

Chen, Lubin; Wimalasena, Nivanthika K; Shim, Jaehoon; Han, Chongyang; Lee, Seong-Il; Gonzalez-Cano, Rafael; Estacion, Mark; Faber, Catharina G; Lauria, Giuseppe; Dib-Hajj, Sulayman D; Woolf, Clifford J; Waxman, Stephen G

Chen, Lubin; Wimalasena, Nivanthika K; Shim, Jaehoon; Han, Chongyang; Lee, Seong-Il; Gonzalez-Cano, Rafael; Estacion, Mark; Faber, Catharina G; Lauria, Giuseppe; Dib-Hajj, Sulayman D; Woolf, Clifford J; Waxman, Stephen G.

Affiliation

Chen L; Department of Neurology, Yale University School of Medicine, New Haven, CT, United States.
Wimalasena NK; Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, United States.
Shim J; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT, United States.
Han C; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, United States.
Lee SI; Department of Neurobiology, Harvard Medical School, Boston, MA, United States.
Gonzalez-Cano R; FM Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, United States.
Estacion M; Department of Neurobiology, Harvard Medical School, Boston, MA, United States.
Faber CG; Department of Neurology, Yale University School of Medicine, New Haven, CT, United States.
Lauria G; Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, United States.
Dib-Hajj SD; Center for Rehabilitation Research, VA Connecticut Healthcare System, West Haven, CT, United States.
Woolf CJ; Department of Neurology, Yale University School of Medicine, New Haven, CT, United States.
Waxman SG; Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, United States.

Pain ; 162(6): 1758-1770, 2021 06 01.

Article de En | MEDLINE | ID: mdl-33323889

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Canal sodique voltage-dépendant NAV1.7 / Ganglions sensitifs des nerfs spinaux Limites: Animals / Humans Langue: En Journal: Pain Année: 2021 Type de document: Article Pays d'affiliation: États-Unis d'Amérique Pays de publication: États-Unis d'Amérique

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