Disseminated Mycobacterium marinum in Human Immunodeficiency Virus Unmasked by Immune Reconstitution Inflammatory Syndrome.
J Infect Dis
; 224(3): 453-457, 2021 08 02.
Article
de En
| MEDLINE
| ID: mdl-33336253
ABSTRACT
Distinguishing disseminated Mycobacterium marinum from multifocal cutaneous disease in persons with human immunodeficiency virus/AIDS can present a diagnostic challenge, especially in the context of immune reconstitution inflammatory syndrome (IRIS). In this work, we demonstrate the utility of flow cytometry and whole genome sequencing (WGS) to diagnose disseminated M. marinum unmasked by IRIS following initiation of antiretroviral therapy. Flow cytometry demonstrated robust cytokine production by CD4 T cells in response to stimulation with M. marinum lysate. WGS of isolates from distinct lesions was consistent with clonal dissemination, supporting that preexisting disseminated M. marinum disease was uncovered by inflammatory manifestations, consistent with unmasking mycobacterial IRIS.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Mycobacterium marinum
/
Syndrome inflammatoire de restauration immunitaire
Type d'étude:
Diagnostic_studies
Limites:
Humans
Langue:
En
Journal:
J Infect Dis
Année:
2021
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique