Serum amyloid A level correlates with T2 lesion volume and cortical volume in patients with multiple sclerosis.
J Neuroimmunol
; 351: 577466, 2021 02 15.
Article
de En
| MEDLINE
| ID: mdl-33370672
ABSTRACT
It is unclear whether brain atrophy in multiple sclerosis (MS) is associated with not only neuroinflammation but also systemic inflammation. Here we found that systemic inflammatory marker serum amyloid A (SAA) was moderately correlated with cortical volume in the patients with clinically isolated syndrome (CIS) and MS (r = -0.41, p = 0.019). SAA was also significantly correlated with T2 lesion volume (T2LV) even after adjusting for age, disease duration, and disease modifying therapy (p = 0.0050). Thus, systemic inflammation may be associated with cortical atrophy, possibly via an increase in the T2LV in patients with CIS/MS.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Encéphale
/
Protéine amyloïde A sérique
/
Sclérose en plaques
Type d'étude:
Observational_studies
Limites:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
J Neuroimmunol
Année:
2021
Type de document:
Article