Opioid use prior to liver transplant is associated with increased risk of death after transplant.
Am J Surg
; 222(1): 234-240, 2021 07.
Article
de En
| MEDLINE
| ID: mdl-33384155
ABSTRACT
BACKGROUND:
Opioids are generally discouraged and used sparingly in liver transplant (LT) candidates prior to LT. This study examined the relationship between opioid use at the time of LT and graft and patient survival following transplantation.METHODS:
A retrospective single center cohort study of LT recipients from June 2012 to December 2019 was performed. Primary outcomes were graft and patient survival, analyzed with the Kaplan-Meier method and Cox proportional hazards models; primary predictor was active opioid prescription at LT.RESULTS:
751 LT recipients were included; 16% had an opioid prescription at LT. Post-transplant death was significantly greater in opioid users (pvalue<0.001). In a multivariable Cox model examining predictors of death, opioid use remained associated with a significant increase in the risk of death (HR 2.4 CI 1.5-4.0, p < 0.001) even after controlling for other factors.CONCLUSION:
Opioid use at LT is associated with a markedly increased risk of death following transplant.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Douleur
/
Transplantation hépatique
/
Maladie du foie en phase terminale
/
Rejet du greffon
/
Analgésiques morphiniques
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
America do norte
Langue:
En
Journal:
Am J Surg
Année:
2021
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique