IL-2 regulates tumor-reactive CD8<sup>+</sup> T cell exhaustion by activating the aryl hydrocarbon receptor.

Liu, Yuying; Zhou, Nannan; Zhou, Li; Wang, Jing; Zhou, Yabo; Zhang, Tianzhen; Fang, Yi; Deng, Jinwei; Gao, Yunfeng; Liang, Xiaoyu; Lv, Jiadi; Wang, Zhenfeng; Xie, Jing; Xue, Yuanbo; Zhang, Huafeng; Ma, Jingwei; Tang, Ke; Fang, Yiliang; Cheng, Feiran; Zhang, Chengjuan; Dong, Bing; Zhao, Yuzhou; Yuan, Peng; Gao, Quanli; Zhang, Haizeng; Xiao-Feng Qin, F; Huang, Bo

IL-2 regulates tumor-reactive CD8⁺ T cell exhaustion by activating the aryl hydrocarbon receptor.

Liu, Yuying; Zhou, Nannan; Zhou, Li; Wang, Jing; Zhou, Yabo; Zhang, Tianzhen; Fang, Yi; Deng, Jinwei; Gao, Yunfeng; Liang, Xiaoyu; Lv, Jiadi; Wang, Zhenfeng; Xie, Jing; Xue, Yuanbo; Zhang, Huafeng; Ma, Jingwei; Tang, Ke; Fang, Yiliang; Cheng, Feiran; Zhang, Chengjuan; Dong, Bing; Zhao, Yuzhou; Yuan, Peng; Gao, Quanli; Zhang, Haizeng; Xiao-Feng Qin, F; Huang, Bo.

Affiliation

Liu Y; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Zhou N; Clinical Immunology Center, CAMS, Beijing, China.
Zhou L; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Wang J; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Zhou Y; National Cancer Center/Cancer Hospital, CAMS, Beijing, China.
Zhang T; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Fang Y; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Deng J; National Cancer Center/Cancer Hospital, CAMS, Beijing, China.
Gao Y; Weifang Hospital of Traditional Chinese Medicine, Weifang, China.
Liang X; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Lv J; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Wang Z; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Xie J; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Xue Y; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Zhang H; Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.
Ma J; Cancer Hospital of Yunnan Province, Kunming, China.
Tang K; Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Fang Y; Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Cheng F; Department of Biochemistry & Molecular Biology, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
Zhang C; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Dong B; Department of Immunology & National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College, Beijing, China.
Zhao Y; Center of Bio repository, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
Yuan P; Provincial Cooperative Innovation Center for Cancer Chemoprevention, Zhengzhou University, Zhengzhou, China.
Gao Q; Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
Zhang H; Department of Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
Xiao-Feng Qin F; Department of Breast Surgery, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, China.
Huang B; Department of Immunology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China.

Nat Immunol ; 22(3): 358-369, 2021 03.

Article de En | MEDLINE | ID: mdl-33432230

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Lymphocytes TIL / Interleukine-2 / Récepteurs à hydrocarbure aromatique / Lymphocytes T CD8/ / Facteurs de transcription à motif basique hélice-boucle-hélice / Microenvironnement tumoral / Tumeurs Type d'étude: Prognostic_studies Langue: En Journal: Nat Immunol Sujet du journal: ALERGIA E IMUNOLOGIA Année: 2021 Type de document: Article Pays d'affiliation: Chine Pays de publication: États-Unis d'Amérique

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