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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Koenig, Paul-Albert; Das, Hrishikesh; Liu, Hejun; Kümmerer, Beate M; Gohr, Florian N; Jenster, Lea-Marie; Schiffelers, Lisa D J; Tesfamariam, Yonas M; Uchima, Miki; Wuerth, Jennifer D; Gatterdam, Karl; Ruetalo, Natalia; Christensen, Maria H; Fandrey, Caroline I; Normann, Sabine; Tödtmann, Jan M P; Pritzl, Steffen; Hanke, Leo; Boos, Jannik; Yuan, Meng; Zhu, Xueyong; Schmid-Burgk, Jonathan L; Kato, Hiroki; Schindler, Michael; Wilson, Ian A; Geyer, Matthias; Ludwig, Kerstin U; Hällberg, B Martin; Wu, Nicholas C; Schmidt, Florian I.
Affiliation
  • Koenig PA; Core Facility Nanobodies, Medical Faculty, University of Bonn, 53127 Bonn, Germany. pakoenig@uni-bonn.de martin.hallberg@ki.se nicwu@illinois.edu fschmidt@uni-bonn.de.
  • Das H; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Liu H; Department of Cell and Molecular Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Kümmerer BM; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Gohr FN; Institute of Virology, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Jenster LM; German Centre for Infection Research (DZIF), partner site Bonn-Cologne, 53127 Bonn, Germany.
  • Schiffelers LDJ; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Tesfamariam YM; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Uchima M; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Wuerth JD; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Gatterdam K; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Ruetalo N; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Christensen MH; Institute of Structural Biology, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Fandrey CI; Institute for Medical Virology and Epidemiology, Section Molecular Virology, University Hospital Tübingen, 72076 Tübingen, Germany.
  • Normann S; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Tödtmann JMP; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Pritzl S; Institute of Innate Immunity, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Hanke L; Core Facility Nanobodies, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Boos J; Core Facility Nanobodies, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Yuan M; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 17177 Stockholm, Sweden.
  • Zhu X; Institute of Human Genetics, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Schmid-Burgk JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Kato H; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Schindler M; Institute for Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Wilson IA; Institute of Cardiovascular Immunology, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Geyer M; Institute for Medical Virology and Epidemiology, Section Molecular Virology, University Hospital Tübingen, 72076 Tübingen, Germany.
  • Ludwig KU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Hällberg BM; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
  • Wu NC; Institute of Structural Biology, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
  • Schmidt FI; Institute of Human Genetics, Medical Faculty, University of Bonn, 53127 Bonn, Germany.
Science ; 371(6530)2021 02 12.
Article de En | MEDLINE | ID: mdl-33436526
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Anticorps neutralisants / Anticorps à domaine unique / Glycoprotéine de spicule des coronavirus / SARS-CoV-2 / COVID-19 / Anticorps antiviraux Limites: Animals / Humans Langue: En Journal: Science Année: 2021 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Anticorps neutralisants / Anticorps à domaine unique / Glycoprotéine de spicule des coronavirus / SARS-CoV-2 / COVID-19 / Anticorps antiviraux Limites: Animals / Humans Langue: En Journal: Science Année: 2021 Type de document: Article