Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection.
Br J Dermatol
; 184(5): 880-887, 2021 05.
Article
de En
| MEDLINE
| ID: mdl-33448030
ABSTRACT
BACKGROUND:
One of the challenging aspects of SARS-CoV-2 infection is its diverse multisystemic disease presentation.OBJECTIVES:
To evaluate the diagnostic value of cutaneous manifestations of SARS-CoV-2 infection and investigate their duration and timing in relation to other COVID-19 symptoms.METHODS:
We used data from 336 847 UK users of the COVID Symptom Study app to assess the diagnostic value of body rash or an acral rash in SARS-CoV-2 infection, and data from an independent online survey of 11 544 respondents to investigate skin-specific symptoms and collect their photographs.RESULTS:
Using data from the app, we show significant association between skin rashes and a positive swab test result (odds ratio 1·67, 95% confidence interval 1·42-1·97). Strikingly, among the respondents of the independent online survey, we found that 17% of SARS-CoV-2-positive cases reported skin rashes as the first presentation, and 21% as the only clinical sign of COVID-19. Together with the British Association of Dermatologists, we have compiled a catalogue of images of the most common skin manifestations of COVID-19 from 400 individuals (https//covidskinsigns.com), which we have made publicly available to assist clinicians in recognition of this early clinical feature of COVID-19.CONCLUSIONS:
Skin rashes cluster with other COVID-19 symptoms, are predictive of a positive swab test, and occur in a significant number of cases, either alone or before other classical symptoms. Recognizing rashes is important in identifying new and earlier cases of COVID-19.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Exanthème
/
COVID-19
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
Br J Dermatol
Année:
2021
Type de document:
Article
Pays d'affiliation:
Royaume-Uni