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Fatal pyrrolizidine alkaloid poisoning of infants caused by adulterated Senecio coronatus.
Van Schalkwyk, F J; Stander, M A; Nsizwane, M; Mathee, A; Van Wyk, B-E.
Affiliation
  • Van Schalkwyk FJ; Mass Spectrometry Unit, Central Analytical Facility, University of Stellenbosch, Private Bag X1, Matieland, 7600, South Africa.
  • Stander MA; Department of Biochemistry, University of Stellenbosch, Private Bag X1, Matieland, 7600, South Africa; Mass Spectrometry Unit, Central Analytical Facility, University of Stellenbosch, Private Bag X1, Matieland, 7600, South Africa.
  • Nsizwane M; Department of Botany and Plant Biotechnology, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, Johannesburg, South Africa.
  • Mathee A; Department of Botany and Plant Biotechnology, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, Johannesburg, South Africa.
  • Van Wyk BE; Department of Botany and Plant Biotechnology, University of Johannesburg, P.O. Box 524, Auckland Park, 2006, Johannesburg, South Africa. Electronic address: bevanwyk@uj.ac.za.
Forensic Sci Int ; 320: 110680, 2021 Mar.
Article de En | MEDLINE | ID: mdl-33461004
ABSTRACT
Senecio coronatus (known as izonkozonko and ubulibazi in Zulu) is commonly used in traditional medicine in South Africa as purification purgative and enemas for infants during weaning. We show for the first time that this species does not contain pyrrolizidine alkaloids and that reported cases of fatal hepatic sinusoidal obstruction syndrome in infants were caused by wrongly identified Senecio species containing large amounts of retrorsine-N-oxide. A validated ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the detection and quantitation of pyrrolizidine alkaloids is described.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Alcaloïdes de type pyrrolizidine / Senecio / Médecine traditionnelle africaine Limites: Humans / Infant Pays/Région comme sujet: Africa Langue: En Journal: Forensic Sci Int Année: 2021 Type de document: Article Pays d'affiliation: République d'Afrique du Sud
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Alcaloïdes de type pyrrolizidine / Senecio / Médecine traditionnelle africaine Limites: Humans / Infant Pays/Région comme sujet: Africa Langue: En Journal: Forensic Sci Int Année: 2021 Type de document: Article Pays d'affiliation: République d'Afrique du Sud