PAI-1 and tPA gene polymorphisms and susceptibility to chronic obstructive pulmonary disease in a sample of Turkish population.
J Pak Med Assoc
; 70(12(B)): 2310-2315, 2020 Dec.
Article
de En
| MEDLINE
| ID: mdl-33475534
ABSTRACT
OBJECTIVES:
The aim of this study was to assess the influence of plasminogen activator inhibitor-1 (PAI-1) 4G/5G or tissue plasminogen activator (tPA) I/D polymorphisms in chronic obstructive pulmonary disease (COPD) cases in a sample of Turkish population.METHODS:
PAI-1 4G/5G and tPA Alu-repeat I/D genetic polymorphisms in 153 COPD subjects and 160 controls were investigated using PCR-RFLP and PCR methods, respectively.RESULTS:
4G allele frequency was 0.62 and 0.39 for COPD and control groups, respectively. 4G allele had an estimated 2.56- fold [95% CI = 1.85-3.53] increased risk of COPD. tPA I allele frequency was 0.55 and 0.50, for COPD and control groups, respectively. I allele had an estimated 1.19-fold [95% CI = 0.87-1.62] increased risk of COPD.CONCLUSIONS:
PAI-1 4G/4G and 4G/5G genotypes seemed to play a key role in the pathophysiology of COPD in Turkish individuals.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Activateur tissulaire du plasminogène
/
Broncho-pneumopathie chronique obstructive
Limites:
Humans
Langue:
En
Journal:
J Pak Med Assoc
Année:
2020
Type de document:
Article
Pays d'affiliation:
Turquie