Methadone effectively attenuates acute and long-term consequences of neonatal repetitive procedural pain in a rat model.
Pediatr Res
; 89(7): 1681-1686, 2021 05.
Article
de En
| MEDLINE
| ID: mdl-33504957
ABSTRACT
BACKGROUND:
Painful procedures in early life cause acute pain and can alter pain processing at a spinal level lasting into adulthood. Current methods of analgesia seem unable to prevent both acute and long-term hypersensitivity associated with neonatal pain. The current study aims to prevent acute and long-term hypersensitivity associated with neonatal procedural pain using methadone analgesia in rat pups.METHODS:
Sprague-Dawley rat pups received either methadone (1 mg/kg) or saline prior to repetitive needle pricks into the left hind paw from the day of birth (postnatal day (P)0) to P7. Control littermates received a tactile stimulus. Mechanical sensitivity was assessed during the neonatal period (P0-P7), from weaning to adulthood (3-7 weeks) and following surgical re-injury of the same dermatome in adulthood.RESULTS:
Methadone administration completely reversed acute hypersensitivity from P0 to P7. In addition, neonatal methadone analgesia prevented prolonged hypersensitivity after re-injury in adulthood, without affecting sensitivity from weaning to adulthood.CONCLUSIONS:
The current study shows that neonatal methadone analgesia can attenuate acute as well as long-term hypersensitivity associated with neonatal procedural pain in a rat model. IMPACT Methadone treatment attenuates acute and long-term hypersensitivity associated with neonatal pain in a rat model. Clinical effectiveness studies are urgently warranted to assess acute and long-term analgesic effectivity of methadone.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Gestion de la douleur
/
Douleur liée aux interventions
/
Analgésiques morphiniques
/
Méthadone
Limites:
Animals
Langue:
En
Journal:
Pediatr Res
Année:
2021
Type de document:
Article
Pays d'affiliation:
Pays-Bas