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Synthesis and evaluation of azalamellarin N and its A-ring-modified analogues as non-covalent inhibitors of the EGFR T790M/L858R mutant.
Fukuda, Tsutomu; Anzai, Mizuho; Nakahara, Akane; Yamashita, Kentaro; Matsukura, Kazuaki; Ishibashi, Fumito; Oku, Yusuke; Nishiya, Naoyuki; Uehara, Yoshimasa; Iwao, Masatomo.
Affiliation
  • Fukuda T; Environmental Protection Center, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. Electronic address: t-fukuda@nagasaki-u.ac.jp.
  • Anzai M; Division of Chemistry and Materials Science, Graduate School of Engineering, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
  • Nakahara A; Division of Chemistry and Materials Science, Graduate School of Engineering, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
  • Yamashita K; Division of Chemistry and Materials Science, Graduate School of Engineering, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
  • Matsukura K; Division of Marine Life Science and Biochemistry, Graduate School of Fisheries and Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
  • Ishibashi F; Division of Marine Life Science and Biochemistry, Graduate School of Fisheries and Environmental Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
  • Oku Y; Department of Integrated Information for Pharmaceutical Sciences, Iwate Medical University School of Pharmacy, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate 028-3694, Japan.
  • Nishiya N; Department of Integrated Information for Pharmaceutical Sciences, Iwate Medical University School of Pharmacy, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate 028-3694, Japan.
  • Uehara Y; Department of Integrated Information for Pharmaceutical Sciences, Iwate Medical University School of Pharmacy, 1-1-1 Idaidori, Yahaba-cho, Shiwa-gun, Iwate 028-3694, Japan.
  • Iwao M; Division of Chemistry and Materials Science, Graduate School of Engineering, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan.
Bioorg Med Chem ; 34: 116039, 2021 03 15.
Article de En | MEDLINE | ID: mdl-33556869
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Inhibiteurs de protéines kinases / Récepteurs ErbB / Composés hétérocycliques avec 4 noyaux ou plus Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Bioorg Med Chem Sujet du journal: BIOQUIMICA / QUIMICA Année: 2021 Type de document: Article Pays de publication: Royaume-Uni
Texte intégral
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XML
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Inhibiteurs de protéines kinases / Récepteurs ErbB / Composés hétérocycliques avec 4 noyaux ou plus Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Bioorg Med Chem Sujet du journal: BIOQUIMICA / QUIMICA Année: 2021 Type de document: Article Pays de publication: Royaume-Uni