SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity.

Ozono, Seiya; Zhang, Yanzhao; Ode, Hirotaka; Sano, Kaori; Tan, Toong Seng; Imai, Kazuo; Miyoshi, Kazuyasu; Kishigami, Satoshi; Ueno, Takamasa; Iwatani, Yasumasa; Suzuki, Tadaki; Tokunaga, Kenzo

Ozono, Seiya; Zhang, Yanzhao; Ode, Hirotaka; Sano, Kaori; Tan, Toong Seng; Imai, Kazuo; Miyoshi, Kazuyasu; Kishigami, Satoshi; Ueno, Takamasa; Iwatani, Yasumasa; Suzuki, Tadaki; Tokunaga, Kenzo.

Affiliation

Ozono S; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Zhang Y; Faculty of Life and Environmental Sciences, University of Yamanashi, Yamanashi, Japan.
Ode H; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Sano K; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi, Japan.
Tan TS; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
Imai K; Division of Infection and Immunity, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Miyoshi K; Self-Defense Forces Central Hospital, Tokyo, Japan.
Kishigami S; Self-Defense Forces Central Hospital, Tokyo, Japan.
Ueno T; Faculty of Life and Environmental Sciences, University of Yamanashi, Yamanashi, Japan.
Iwatani Y; Division of Infection and Immunity, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
Suzuki T; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi, Japan.
Tokunaga K; Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.

Nat Commun ; 12(1): 848, 2021 02 08.

Article de En | MEDLINE | ID: mdl-33558493

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pénétration virale / Glycoprotéine de spicule des coronavirus / Angiotensin-converting enzyme 2 / SARS-CoV-2 / COVID-19 / Mutation Type d'étude: Prognostic_studies Limites: Humans Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2021 Type de document: Article Pays d'affiliation: Japon Pays de publication: Royaume-Uni

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