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Nerve Fibers in the Tumor Microenvironment Are Co-Localized with Lymphoid Aggregates in Pancreatic Cancer.
Heij, Lara R; Tan, Xiuxiang; Kather, Jakob N; Niehues, Jan M; Sivakumar, Shivan; Heussen, Nicole; van der Kroft, Gregory; Damink, Steven W M Olde; Lang, Sven; Aberle, Merel R; Luedde, Tom; Gaisa, Nadine T; Bednarsch, Jan; Liu, Drolaiz H W; Cleutjens, Jack P M; Modest, Dominik P; Neumann, Ulf P; Wiltberger, Georg J.
Affiliation
  • Heij LR; Department of General, Gastrointestinal, Hepatobiliary and Transplant Surgery, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  • Tan X; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6229 ER Maastricht, The Netherlands.
  • Kather JN; Institute of Pathology, RWTH Aachen University, 52074 Aachen, Germany.
  • Niehues JM; Department of General, Gastrointestinal, Hepatobiliary and Transplant Surgery, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  • Sivakumar S; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6229 ER Maastricht, The Netherlands.
  • Heussen N; Department of Medicine III, University Hospital RWTH Aachen, 52074 Aachen, Germany.
  • van der Kroft G; Department of Medicine III, University Hospital RWTH Aachen, 52074 Aachen, Germany.
  • Damink SWMO; Department of Oncology, University of Oxford, Oxford OX3 7DQ, UK.
  • Lang S; Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.
  • Aberle MR; Department of Medical Statistics, RWTH Aachen University, 52074 Aachen, Germany.
  • Luedde T; Center of Biostatistics and Epidemiology, Medical School, Sigmund Freud University, 1020 Vienna, Austria.
  • Gaisa NT; Department of General, Gastrointestinal, Hepatobiliary and Transplant Surgery, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  • Bednarsch J; Department of General, Gastrointestinal, Hepatobiliary and Transplant Surgery, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  • Liu DHW; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6229 ER Maastricht, The Netherlands.
  • Cleutjens JPM; Department of Surgery, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.
  • Modest DP; Department of General, Gastrointestinal, Hepatobiliary and Transplant Surgery, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  • Neumann UP; Department of General, Gastrointestinal, Hepatobiliary and Transplant Surgery, RWTH Aachen University Hospital, 52074 Aachen, Germany.
  • Wiltberger GJ; NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6229 ER Maastricht, The Netherlands.
J Clin Med ; 10(3)2021 Jan 30.
Article de En | MEDLINE | ID: mdl-33573277
ABSTRACT
B cells and tertiary lymphoid structures (TLS) are reported to be important in survival in cancer. Pancreatic Cancer (PDAC) is one of the most lethal cancer types, and currently, it is the seventh leading cause of cancer-related death worldwide. A better understanding of tumor biology is pivotal to improve clinical outcome. The desmoplastic stroma is a complex system in which crosstalk takes place between cancer-associated fibroblasts, immune cells and cancer cells. Indirect and direct cellular interactions within the tumor microenvironment (TME) drive key processes such as tumor progression, metastasis formation and treatment resistance. In order to understand the aggressiveness of PDAC and its resistance to therapeutics, the TME needs to be further unraveled. There are some limited data about the influence of nerve fibers on cancer progression. Here we show that small nerve fibers are located at lymphoid aggregates in PDAC. This unravels future pathways and has potential to improve clinical outcome by a rational development of new therapeutic strategies.
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: J Clin Med Année: 2021 Type de document: Article Pays d'affiliation: Allemagne
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Langue: En Journal: J Clin Med Année: 2021 Type de document: Article Pays d'affiliation: Allemagne