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16-Picolyl-androsterone derivative exhibits potent 17ß-HSD3 inhibitory activity, improved metabolic stability and cytotoxic effect on various cancer cells: Synthesis, homology modeling and docking studies.
Cortés-Benítez, Francisco; Roy, Jenny; Perreault, Martin; Maltais, René; Poirier, Donald.
Affiliation
  • Cortés-Benítez F; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU De Québec - Research Center, Québec City, Québec, G1V 4G2, Canada; Laboratory of Synthesis and Isolation of Bioactive Substances, Department of Biological Systems, Biological and Health Sciences Division, Metropolitan Autonomo
  • Roy J; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU De Québec - Research Center, Québec City, Québec, G1V 4G2, Canada.
  • Perreault M; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU De Québec - Research Center, Québec City, Québec, G1V 4G2, Canada.
  • Maltais R; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU De Québec - Research Center, Québec City, Québec, G1V 4G2, Canada.
  • Poirier D; Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU De Québec - Research Center, Québec City, Québec, G1V 4G2, Canada; Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec City, Québec, G1V 0A6, Canada. Electronic address: donald.poirier@crchudequebec
J Steroid Biochem Mol Biol ; 210: 105846, 2021 06.
Article de En | MEDLINE | ID: mdl-33609690
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Antienzymes / 17-Hydroxysteroid dehydrogenases / Androstérone / Antinéoplasiques Limites: Animals / Humans / Male Langue: En Journal: J Steroid Biochem Mol Biol Sujet du journal: BIOLOGIA MOLECULAR / BIOQUIMICA Année: 2021 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Antienzymes / 17-Hydroxysteroid dehydrogenases / Androstérone / Antinéoplasiques Limites: Animals / Humans / Male Langue: En Journal: J Steroid Biochem Mol Biol Sujet du journal: BIOLOGIA MOLECULAR / BIOQUIMICA Année: 2021 Type de document: Article