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Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis.
Zheng, Shihong; Cao, Peichang; Yin, Zequn; Wang, Xuerui; Chen, Yuanli; Yu, Maoyun; Xu, Baocai; Liao, Chenzhong; Duan, Yajun; Zhang, Shuang; Han, Jihong; Yang, Xiaoxiao.
Affiliation
  • Zheng S; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. xiaoxiaoyang@hfut.edu.cn.
  • Cao P; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. xiaoxiaoyang@hfut.edu.cn.
  • Yin Z; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. xiaoxiaoyang@hfut.edu.cn.
  • Wang X; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. xiaoxiaoyang@hfut.edu.cn.
  • Chen Y; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. xiaoxiaoyang@hfut.edu.cn.
  • Yu M; School of Biological and Pharmaceutical Engineering, West Anhui University, Lu'an, China.
  • Xu B; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. xiaoxiaoyang@hfut.edu.cn.
  • Liao C; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. xiaoxiaoyang@hfut.edu.cn.
  • Duan Y; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. xiaoxiaoyang@hfut.edu.cn.
  • Zhang S; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. xiaoxiaoyang@hfut.edu.cn.
  • Han J; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. xiaoxiaoyang@hfut.edu.cn and College of Life Sciences, Key Laboratory of Medicinal Chemical Biology, Key Labo
  • Yang X; Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes, College of Food and Biological Engineering, Hefei University of Technology, Hefei, China. xiaoxiaoyang@hfut.edu.cn.
Food Funct ; 12(5): 2323-2334, 2021 Mar 15.
Article de En | MEDLINE | ID: mdl-33620063
Cholestasis can induce liver fibrosis and cirrhosis. Apigenin has anti-oxidant and anti-inflammatory effects. Herein, we determined whether apigenin can protect mice against cholestasis. In vitro, apigenin protected TFK-1 cells (a human bile duct cancer cell line) against H2O2-induced ROS generation and inhibited transforming growth factor-ß-activated collagen type 1 alpha 1 and α-smooth muscle actin in LX2 cells (a human hepatic stellate cell line). In vivo, cholestatic mice induced by 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) were treated with apigenin. Apigenin potently blocked DDC-induced gallbladder atrophy and associated liver injury, fibrosis and collagen accumulation. Moreover, apigenin relieved the DDC-caused abnormality of bile acid metabolism and restored the balance between bile secretion and excretion by regulating the farnesoid X receptor signaling pathway. Furthermore, apigenin reduced inflammation or oxidative stress in the liver by blocking the DDC-activated Toll-like receptor 4, nuclear factor κB and tumor necrosis factor α, or DDC-suppressed superoxidase dismutase 1/2, catalase and glutathione peroxidase. Taken together, apigenin improves DDC-induced cholestasis by reducing inflammation and oxidative damage and improving bile acid metabolism, indicating its potential application for cholestasis treatment.
Sujet(s)

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyridines / Cholestase / Agents protecteurs / Apigénine Limites: Animals / Humans / Male Langue: En Journal: Food Funct Année: 2021 Type de document: Article Pays d'affiliation: Chine Pays de publication: Royaume-Uni

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Pyridines / Cholestase / Agents protecteurs / Apigénine Limites: Animals / Humans / Male Langue: En Journal: Food Funct Année: 2021 Type de document: Article Pays d'affiliation: Chine Pays de publication: Royaume-Uni