Genome-wide CRISPR/Cas9 knockout screening uncovers a novel inflammatory pathway critical for resistance to arginine-deprivation therapy.

Chu, Cheng-Ying; Lee, Yi-Ching; Hsieh, Cheng-Han; Yeh, Chi-Tai; Chao, Tsu-Yi; Chen, Po-Hung; Lin, I-Hsuan; Hsieh, Tsung-Han; Shih, Jing-Wen; Cheng, Chia-Hsiung; Chang, Che-Chang; Lin, Ping-Sheng; Huang, Yuan-Li; Chen, Tsung-Ming; Yen, Yun; Ann, David K; Kung, Hsing-Jien

Chu, Cheng-Ying; Lee, Yi-Ching; Hsieh, Cheng-Han; Yeh, Chi-Tai; Chao, Tsu-Yi; Chen, Po-Hung; Lin, I-Hsuan; Hsieh, Tsung-Han; Shih, Jing-Wen; Cheng, Chia-Hsiung; Chang, Che-Chang; Lin, Ping-Sheng; Huang, Yuan-Li; Chen, Tsung-Ming; Yen, Yun; Ann, David K; Kung, Hsing-Jien.

Affiliation

Chu CY; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 110, Taiwan.
Lee YC; CRISPR Gene Targeting Core Lab, Taipei Medical University, Taipei 110, Taiwan.
Hsieh CH; CRISPR Gene Targeting Core Lab, Taipei Medical University, Taipei 110, Taiwan.
Yeh CT; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chao TY; Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City.
Chen PH; Department of Hematology & Oncology, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan.
Lin IH; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan.
Hsieh TH; Department of Medical Research & Education, Taipei Medical University - Shuang Ho Hospital, New Taipei City.
Shih JW; Department of Hematology & Oncology, Taipei Medical University - Shuang Ho Hospital, New Taipei City, Taiwan.
Cheng CH; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei City, Taiwan.
Chang CC; Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
Lin PS; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 110, Taiwan.
Huang YL; Bioinformatics Core Facility, The University of Manchester, Manchester, United Kingdom.
Chen TM; Joint Biobank, Office of Human Research, Taipei Medical University, Taipei, Taiwan.
Yen Y; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taipei 110, Taiwan.
Ann DK; Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan.
Kung HJ; Graduate Institute of Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei 110, Taiwan.

Theranostics ; 11(8): 3624-3641, 2021.

Article de En | MEDLINE | ID: mdl-33664852

Sujet(s)
Mots clés

ADI resistance; CCL2; CRISPR/Cas9; TREM1; arginine starvation

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Arginine / Polyéthylène glycols / Hydrolases Type d'étude: Diagnostic_studies / Prognostic_studies / Screening_studies Langue: En Journal: Theranostics Année: 2021 Type de document: Article Pays d'affiliation: Taïwan Pays de publication: Australie

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