Synthesis of (+)-Muconin via Diastereoselective Oxypalladation.
J Org Chem
; 86(6): 4859-4866, 2021 03 19.
Article
de En
| MEDLINE
| ID: mdl-33667103
ABSTRACT
Synthesis of (+)-muconin isolated from Rollinia mucosa (Annonaceae) was achieved. Stereoselective construction of a tetrahydrofuran-terahydropyran (THF-THP) ring moiety was performed using diastereoselective oxypalladation in the presence of CuCl2. The cross-coupling reaction of the THF-THP moiety with the γ-lactone portion followed by reduction of the enyne and removal of the protecting groups afforded (+)-muconin.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Annonaceae
/
Lactones
Langue:
En
Journal:
J Org Chem
Année:
2021
Type de document:
Article
Pays d'affiliation:
Japon