MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2.

Uemura, Kentaro; Sasaki, Michihito; Sanaki, Takao; Toba, Shinsuke; Takahashi, Yoshimasa; Orba, Yasuko; Hall, William W; Maenaka, Katsumi; Sawa, Hirofumi; Sato, Akihiko

Uemura, Kentaro; Sasaki, Michihito; Sanaki, Takao; Toba, Shinsuke; Takahashi, Yoshimasa; Orba, Yasuko; Hall, William W; Maenaka, Katsumi; Sawa, Hirofumi; Sato, Akihiko.

Affiliation

Uemura K; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd, Osaka, Japan.
Sasaki M; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Sanaki T; Laboratory of Biomolecular Science, Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Toba S; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Takahashi Y; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd, Osaka, Japan.
Orba Y; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Hall WW; Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd, Osaka, Japan.
Maenaka K; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.
Sawa H; Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan.
Sato A; Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo, Japan.

Sci Rep ; 11(1): 5376, 2021 03 08.

Article de En | MEDLINE | ID: mdl-33686154

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Antiviraux / Découverte de médicament / Ingénierie cellulaire / Angiotensin-converting enzyme 2 / SARS-CoV-2 / Modèles biologiques Limites: Animals / Humans Langue: En Journal: Sci Rep Année: 2021 Type de document: Article Pays d'affiliation: Japon Pays de publication: Royaume-Uni

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