DUOX1 in mammalian disease pathophysiology.
J Mol Med (Berl)
; 99(6): 743-754, 2021 06.
Article
de En
| MEDLINE
| ID: mdl-33704512
ABSTRACT
Dual oxidase 1 (DUOX1) is a member of the protein family of nicotinamide adenine dinucleotide phosphate (NADPH) oxidases. DUOX1 has several normal physiological, immunological, and biochemical functions in different parts of the body. Dysregulated oxidative metabolism interferes with various disease pathologies and numerous therapeutic options are based on targeting cellular redox pathways. DUOX1 forms an important enzymatic source of biological oxidants, and DUOX1 expression is frequently dysregulated in various diseases. While this review shortly addresses the biochemical and cellular properties and proposed physiological roles of DUOX1, its main purpose is to summarize the current knowledge with respect to the potential role of DUOX1 enzyme in disease pathology, especially in mammalian organisms. Although DUOX1 is normally prominently expressed in epithelial lineages, it is frequently silenced in epithelial-derived cancers by epigenetic mechanisms. While an abundance of information is available on DUOX1 transcription in different diseases, an increasing number of mechanistic studies indicate a causative relationship between DUOX1 function and disease pathophysiology. Additionally, specific functions of the DUOX1 maturation factor, DUOXA1, will also be addressed. Lastly, urgent and outstanding questions on the field of DUOX1 will be discussed that could provide valuable new diagnostic tools and novel therapeutic options.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Oxydoréduction
/
Régulation de l'expression des gènes codant pour des enzymes
/
Prédisposition aux maladies
/
Dual oxydases
Limites:
Animals
/
Humans
Langue:
En
Journal:
J Mol Med (Berl)
Sujet du journal:
BIOLOGIA MOLECULAR
/
GENETICA MEDICA
Année:
2021
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique