Engineering biomaterials to prevent post-operative infection and fibrosis.
Drug Deliv Transl Res
; 11(4): 1675-1688, 2021 08.
Article
de En
| MEDLINE
| ID: mdl-33710589
ABSTRACT
Implantable biomaterials are essential surgical devices, extending and improving the quality of life of millions of people globally. Advances in materials science, manufacturing, and in our understanding of the biological response to medical device implantation over several decades have resulted in improved safety and functionality of biomaterials. However, post-operative infection and immune responses remain significant challenges that interfere with biomaterial functionality and host healing processes. The objectives of this review is to provide an overview of the biology of post-operative infection and the physiological response to implanted biomaterials and to discuss emerging strategies utilizing local drug delivery and surface modification to improve the long-term safety and efficacy of biomaterials.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Qualité de vie
/
Matériaux biocompatibles
Aspects:
Patient_preference
Limites:
Humans
Langue:
En
Journal:
Drug Deliv Transl Res
Année:
2021
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique