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Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.
Grohmann, Christoph; Walker, Francesca; Devlin, Mark; Luo, Meng-Xiao; Chüeh, Anderly C; Doherty, Judy; Vaillant, François; Ho, Gwo-Yaw; Wakefield, Matthew J; Weeden, Clare E; Kamili, Alvin; Murray, Jayne; Po'uha, Sela T; Weinstock, Janet; Kane, Serena R; Faux, Maree C; Broekhuizen, Esmee; Zheng, Ye; Shield-Artin, Kristy; Kershaw, Nadia J; Tan, Chin Wee; Witchard, Helen M; Ebert, Gregor; Charman, Susan A; Street, Ian; Kavallaris, Maria; Haber, Michelle; Fletcher, Jamie I; Asselin-Labat, Marie-Liesse; Scott, Clare L; Visvader, Jane E; Lindeman, Geoffrey J; Watson, Keith G; Burgess, Antony W; Lessene, Guillaume.
Affiliation
  • Grohmann C; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia. grohmann.c@wehi.edu.au.
  • Walker F; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia. grohmann.c@wehi.edu.au.
  • Devlin M; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
  • Luo MX; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.
  • Chüeh AC; Ludwig Institute for Cancer Research, Melbourne, VIC, 3000, Australia.
  • Doherty J; Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre building, Melbourne, 3000, Australia.
  • Vaillant F; Cancer Therapeutics CRC, Melbourne, VIC, 3000, Australia.
  • Ho GY; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
  • Wakefield MJ; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.
  • Weeden CE; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
  • Kamili A; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.
  • Murray J; Cancer Therapeutics CRC, Melbourne, VIC, 3000, Australia.
  • Po'uha ST; Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre building, Melbourne, 3000, Australia.
  • Weinstock J; Cancer Therapeutics CRC, Melbourne, VIC, 3000, Australia.
  • Kane SR; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
  • Faux MC; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.
  • Broekhuizen E; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
  • Zheng Y; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.
  • Shield-Artin K; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
  • Kershaw NJ; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.
  • Tan CW; The University of Melbourne, Department of Obstetrics and Gynaecology, Parkville, VIC, 3050, Australia.
  • Witchard HM; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
  • Ebert G; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.
  • Charman SA; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia.
  • Street I; School of Women's and Children's Health, UNSW, Sydney, NSW, 2052, Australia.
  • Kavallaris M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia.
  • Haber M; Children's Cancer Institute, Lowy Cancer Research Centre, UNSW, Sydney, NSW, 2052, Australia.
  • Fletcher JI; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
  • Asselin-Labat ML; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.
  • Scott CL; Ludwig Institute for Cancer Research, Melbourne, VIC, 3000, Australia.
  • Visvader JE; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
  • Lindeman GJ; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.
  • Watson KG; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
  • Burgess AW; The University of Melbourne, Department of Medical Biology, Parkville, VIC, 3050, Australia.
  • Lessene G; Walter and Eliza Hall Institute, Parkville, VIC, 3052, Australia.
Cell Death Dis ; 12(3): 268, 2021 03 12.
Article de En | MEDLINE | ID: mdl-33712556
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Résistance aux médicaments antinéoplasiques / Antimitotiques / Tumeurs Limites: Animals / Female / Humans Langue: En Journal: Cell Death Dis Année: 2021 Type de document: Article Pays d'affiliation: Australie Pays de publication: Royaume-Uni
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Résistance aux médicaments antinéoplasiques / Antimitotiques / Tumeurs Limites: Animals / Female / Humans Langue: En Journal: Cell Death Dis Année: 2021 Type de document: Article Pays d'affiliation: Australie Pays de publication: Royaume-Uni