Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome.

Inak, Gizem; Rybak-Wolf, Agnieszka; Lisowski, Pawel; Pentimalli, Tancredi M; Jüttner, René; Glazar, Petar; Uppal, Karan; Bottani, Emanuela; Brunetti, Dario; Secker, Christopher; Zink, Annika; Meierhofer, David; Henke, Marie-Thérèse; Dey, Monishita; Ciptasari, Ummi; Mlody, Barbara; Hahn, Tobias; Berruezo-Llacuna, Maria; Karaiskos, Nikos; Di Virgilio, Michela; Mayr, Johannes A; Wortmann, Saskia B; Priller, Josef; Gotthardt, Michael; Jones, Dean P; Mayatepek, Ertan; Stenzel, Werner; Diecke, Sebastian; Kühn, Ralf; Wanker, Erich E; Rajewsky, Nikolaus; Schuelke, Markus; Prigione, Alessandro

Inak, Gizem; Rybak-Wolf, Agnieszka; Lisowski, Pawel; Pentimalli, Tancredi M; Jüttner, René; Glazar, Petar; Uppal, Karan; Bottani, Emanuela; Brunetti, Dario; Secker, Christopher; Zink, Annika; Meierhofer, David; Henke, Marie-Thérèse; Dey, Monishita; Ciptasari, Ummi; Mlody, Barbara; Hahn, Tobias; Berruezo-Llacuna, Maria; Karaiskos, Nikos; Di Virgilio, Michela; Mayr, Johannes A; Wortmann, Saskia B; Priller, Josef; Gotthardt, Michael; Jones, Dean P; Mayatepek, Ertan; Stenzel, Werner; Diecke, Sebastian; Kühn, Ralf; Wanker, Erich E; Rajewsky, Nikolaus; Schuelke, Markus; Prigione, Alessandro.

Affiliation

Inak G; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Rybak-Wolf A; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
Lisowski P; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine (MDC), Hannoversche Str 28, 10115, Berlin, Germany.
Pentimalli TM; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Jüttner R; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
Glazar P; Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Jastrzebiec, n/Warsaw, Magdalenka, Poland.
Uppal K; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine (MDC), Hannoversche Str 28, 10115, Berlin, Germany.
Bottani E; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Brunetti D; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine (MDC), Hannoversche Str 28, 10115, Berlin, Germany.
Secker C; Emory University, Atlanta, GA, USA.
Zink A; Department of Diagnostics and Public Health, University of Verona, Verona, Italy.
Meierhofer D; Mitochondrial Medicine Laboratory, Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy.
Henke MT; Unit of Medical Genetics and Neurogenetics Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.
Dey M; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Ciptasari U; Charité - Universitätsmedizin Berlin, Department of Neurology, Berlin, Germany.
Mlody B; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Hahn T; Department of General Pediatrics, Neonatology and Pediatric Cardiology, Duesseldorf University Hospital, Medical Faculty, Heinrich Heine University, Duesseldorf, Germany.
Berruezo-Llacuna M; Charité - Universitätsmedizin Berlin, Department of Neuropsychiatry, Berlin, Germany.
Karaiskos N; Max Planck Institute for Molecular Genetics, Berlin, Germany.
Di Virgilio M; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Mayr JA; Charité - Universitätsmedizin Berlin, Department of Neuropediatrics, Berlin, Germany.
Wortmann SB; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Priller J; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Gotthardt M; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Jones DP; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Mayatepek E; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Stenzel W; Berlin Institute for Medical Systems Biology (BIMSB), Max Delbrück Center for Molecular Medicine (MDC), Hannoversche Str 28, 10115, Berlin, Germany.
Diecke S; Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany.
Kühn R; University Children's Hospital, Paracelsus Medical University (PMU), Salzburg, Austria.
Wanker EE; University Children's Hospital, Paracelsus Medical University (PMU), Salzburg, Austria.
Rajewsky N; Radboud Center for Mitochondrial Medicine, Department of Pediatrics, Amalia Children's Hospital, Radboudumc, Nijmegen, The Netherlands.
Schuelke M; Charité - Universitätsmedizin Berlin, Department of Neuropsychiatry, Berlin, Germany.
Prigione A; University of Edinburgh and UK DRI, Edinburgh, UK.

Nat Commun ; 12(1): 1929, 2021 03 26.

Article de En | MEDLINE | ID: mdl-33771987

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Maladie de Leigh / Organoïdes / Protéines mitochondriales / Cellules souches pluripotentes induites / Protéines membranaires / Mutation / Neurones Type d'étude: Prognostic_studies Limites: Child, preschool / Humans / Male Langue: En Journal: Nat Commun Sujet du journal: BIOLOGIA / CIENCIA Année: 2021 Type de document: Article Pays d'affiliation: Allemagne Pays de publication: Royaume-Uni

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